The 24 sides through from the group phase join the eight third-placed finishers in the Champions League in Monday's draw, including Manchester United and Ajax Amsterdam.
IMAGES from the EPL matches played on Wednesday.
Manchester United manager Louis van Gaal will delve into the depths of his squad for the visit to Arsenal in the Premier League on Saturday, as an injury crisis engulfs Old Trafford.
Substitute Alexandre Lacazette ended his goal drought as Arsenal secured their first English Premier League win since New Year's Day with a 4-0 victory over Newcastle United at the Emirates Stadium on Sunday. Lacazette had gone nine games in all competitions without a goal before he found the target with a mis-hit shot in the final moments of the game. The win moves Arsenal up to tenth position and will give them hope they can make a late push towards European qualification for next season.
A fixture billed as a pre-Christmas cracker was more 'In the Bleak Midwinter' than 'Jingle Bell Rock' as Arsenal's hopes of regaining top spot in the Premier League fizzled out in a turgid 0-0 draw with Chelsea.
IMAGES from the English Premier League matches played on Saturday.
Aston Villa returned to winning ways in stunning fashion as Ollie Watkins scored twice in a 3-0 away thumping of an abject Arsenal in drizzly north London on Sunday.
Images from Saturday's action in the English Premier League.
Images from UEFA Champions League matches played on Wednesday.
Images from the Premier League matches played on Saturday.
Relentless will to improve drives City to greatness
IMAGES from the English Premier League matches played on Saturday.
Liverpool have extended captain Jordan Henderson's contract, the Premier League side said on Tuesday, putting an end to speculation over his future at the Merseyside club.
Hazard extra-time goal sends 10-man Real Madrid through to Copa del Rey final.
Holders Arsenal won the FA Cup for a record 12th time on Saturday, outclassing Aston Villa 4-0 at Wembley with stunning goals from Theo Walcott and Alexis Sanchez setting up their one-sided victory.
IMAGES from the EPL matches played on Sunday.
Arsenal midfielder Jack Wilshere will be out of action for three months after undergoing ankle surgery, the Premier League club said on Thursday.
IMAGES from English Premier League matches played on Sunday.
News of all that transpired on and off the football field on Friday
IMAGES from the English Premier League matches played on Wednesday.
News of all that's transpired on and off the football field.
Arsenal extend Aubameyang stay with new three-year deal
Images from Saturday's action in the Premier League.
Chelsea have signed Germany's highly-rated attacking midfielder Kai Havertz from Bundesliga side Bayer Leverkusen on a five-year contract, the Premier League club announced on Friday.
Images from UEFA Europa League semi-finals played on Thursday.
Champions Liverpool were ripped apart 7-2 at Aston Villa and Manchester United were humiliated 6-1 at home by Tottenham Hotspur on Sunday in one of the most astonishing days of Premier League results.
News of all that transpired on and off the football field
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Images from Saturday's action in the English Premier League.
IMAGES from the English Premier League matches played on Saturday.
Premier League champions Liverpool maintained their 100 per cent start to the season with a 3-1 win against Arsenal at Anfield on Monday leaving them level on nine points with pacesetters Everton and Leicester City.
News of all that's transpired on and off the football field.
Arsene Wenger is confident Arsenal can rekindle the art of winning after a series of frustrating Premier League draws but their quest may be hindered by a "worrying" injury crisis.
Images from the EPL matches played on Saturday
Chelsea is currently at the fourth place in the Premier League standings with 63 points from 37 matches.
Images from Sunday's action in the English Premier League.
Images from the English Premier League matches played on Saturday.
Watford's hopes of avoiding relegation suffered a double blow on Tuesday when they were thrashed 4-0 at home by Manchester City and then slipped into the Premier League relegation zone after fellow strugglers Aston Villa beat Arsenal in the late game.
Jamie Vardy equalled the English Premier League record by scoring for a 10th successive match as his Leicester City side went top after winning 3-0 at Newcastle United while champions Chelsea ended their slump with a 1-0 win over Norwich City on Saturday.
News of all that transpired on and off the football field.